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An over-the-counter oral antihistamine like cetirizine (Zyrtec), loratadine (Claritin), or diphenhydramine (Benadryl) reduces histamine activity systemically and can relieve injection site itching within 30 to 60 minutes

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Twenty-four participants were randomized within three weekly dose cohorts (15 mg, 30 mg, and 30/60 mg