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It is likely that the receptor reserve in the HEK-293 expression system enables the detection of agonists with low efficacy and therefore provides a useful environment in which to distinguish affinity-generating determinants from those responsible for creating efficacy

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The new formulation, which was authorized based on a combination of manufacturing and preclinical data, as well as previous clinical, non-clinical and real-world evidence, is expected to be available in the U.S